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TAT Complex Paired Antibody Set
货号:TAT-EIA | 规格:5 plates | 价格:¥0.00 | 品牌:Affinity Biologicals
Affinity Biologicals TAT Complex Paired Antibody Set/TAT Complex抗体对由匹配的捕获抗体和检测抗体组成,经过滴定和优化,用于夹心ELISA检测。

TAT Complex抗体对,   TAT Complex配对抗体

Matched-Pair Antibody Set for ELISA of human Thrombin-Antithrombin complex (TAT)

Affinity Biologicals TAT Complex Paired Antibody Set抗体对由匹配的捕获抗体和检测抗体组成,抗体已经过滴定和优化用于夹心ELISA检测。

A1AT配对抗体包含有足够5 x 96孔板使用的捕获抗体和检测抗体,提供有详细的操作说明,溶液配方和所需其他材料的来源。

Factor IX配对抗体旨在用于实验室建立研究目的的内部免疫测定,不能用于诊断应用。


TAT Complex抗体对的组分:

Capture Antibody(TAT-EIA-C): 1 x 0.5 mL多克隆亲和纯化anti-thrombin antibody, 用于包被板。

Detecting Antibody(TAT-EIA-D): 1 x 0.5 mL过氧化物酶标记亲和纯化的多克隆anti-ATIII antibody, 用于检测捕获的TAT complex。

Conjugate Diluent: 5 x 10 mL, 每管含10 mL过氧化物酶偶联抗体通用稀释液。每管足够一个96孔板使用。

性状: 液体

储存: 2°C至8°C


Thrombin-Antithrombin complex (TAT)描述:

The activation of coagulation ultimately leads to the activation of prothrombin to the enzyme thrombin. Unless regulated, thrombin will act on its natural substrates that include fibrinogen, factor V, factor VIII, factor XIII, Protein C, TAFI as well as specific receptors on platelets and endothelial cells. The activity of thrombin in plasma is regulated in part through interaction with protease inhibitors. Based on kinetic rates and physiological concentrations, the primary inhibitor of thrombin in plasma is antithrombin (ATIII), followed by heparin cofactor II and alpha-2-macroglobulin.

 

The thrombin-antithrombin complex (TAT) results when thrombin cleaves a scissile bond near the C-terminus of ATIII, forming a covalent, 1:1 acyl enzyme intermediate with ATIII with an apparent mass of 96 kDa. Calcium is not required for this interaction, but the rate of thrombin inhibition by ATIII can be accelerated 1000-fold by optimal concentrations of heparin. Although TAT complex is relatively stable, under conditions of elevated pH and/or enzyme excess, enzymatic degradation and even dissociation of the complex can occur. In serum, vitronectin (also known as S-Protein) has been reported to form larger ternary complexes with TAT (350 kDa), but these ternary S-TAT complexes are not covalently linked and are not stable to denaturants such as SDS. TAT complex is cleared from circulation by serpin-enzyme complex receptors on the surface of hepatocytes, with a half-life of 15 minutes.





Paired Antibody Set, Antibody pair

配对抗体(抗体对)是指可以同时结合在一个抗原分子的不同抗原决定簇的两个抗体, 一对配对抗体对包括捕获抗体和检测抗体。


Affinity Biologicals是全球血栓形成和止血研究及诊断产品的主要生产商,产品包括凝血和止血相关蛋白抗体,偶联物,用于人和动物免疫分析的抗体对(Antibody Pairs),VisuLize系列凝血因子抗原ELISA试剂盒。

北京中昊新生科技作为加拿大Affinity Biologicals中国代理, 一直致力于为客户提供及时高效的配送和更专业的产品使用过程中的技术支持,联系我们了解TAT Complex Paired Antibody Set,TAT Complex抗体对最新现货优惠信息。

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