Human PAI-1 (vitronectin binding negative mutant, wild type acti
货号：HPAI-QR
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规格：1.0 mg
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价格：￥0.00
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品牌：Molecular Innovations
Human PAI-1 (vitronectin binding negative mutant, wild type active fraction)是由北京中昊新生科技有限公司提供，Molecular Innovations专注于凝血和溶栓试剂，包括PAI-894、tPA、尿激酶、凝血因子、玻连蛋白、纤维蛋白原、纤连蛋白、肾素原/肾素、前激肽释放酶、激肽释放酶、白蛋白、纤溶酶原、纤溶酶、抗纤溶酶、凝血酶、抗凝血酶、补体成分和免疫球蛋白。
A double mutation (Q123K and R101A) results in greatly reduced binding of the PAI-1 mutant to the important ligand vitronectin. All other aspects of PAI-1 biological activity such as anti-protease activity remain unaffected.
References
Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal. Jensen JK, Durand MK, Skeldal S, Dupont DM, Bødker JS, Wind T, Andreasen PA. FEBS Lett. 2004 Jan 2;556(1-3):175-9.
Conservation of Critical Functional Domains in Murine Plasminogen Activator Inhibitor-1. Zhi Xu, Rashna D. Balsara, Natalia V. Gorlatova, Daniel A. Lawrence, Francis J. Castellino, and Victoria A. Ploplis. J. Biol. Chem., Apr 2004; 279:17914-20.
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