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Rat Prolactin Receptor, chiMAX Fc Fusion Protein
货号:RPRLR-FC | 规格:0.1 mg | 价格:¥0.00 | 品牌:Molecular Innovations
Rat Prolactin Receptor, chiMAX Fc Fusion Protein是由北京中昊新生科技有限公司提供,Molecular Innovations专注于凝血和溶栓试剂,包括PAI-1759、tPA、尿激酶、凝血因子、玻连蛋白、纤维蛋白原、纤连蛋白、肾素原/肾素、前激肽释放酶、激肽释放酶、白蛋白、纤溶酶原、纤溶酶、抗纤溶酶、凝血酶、抗凝血酶、补体成分和免疫球蛋白。
Prolactin is a neuroendocrine peptide hormone that is secreted primarily by the pituitary gland. Prolactin receptor is a class 1 cytokine transmembrane receptor that varies in size with tissue source and species. It consists of an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region. The extracellular domain (Ser21-Asp229) is expressed recombinantly, purified by chromatography, sterile filtered and lyophilized. >95percent pure by SDS-PAGE and biologically active as measured by inhibitory activity toward prolactin-induced proliferation of Nb2-11 rat lymphoma cells (Gout et al. (1980) Cancer Res. 40:2433). ED50 for this effect is typically < 50 ng/ml in the presence of 0.5 ng/ml of recombinant human Prolactin. Add deionized water to original volume, aliquot and freeze unused portion.

This chiMAX Fc Fusion Protein is glycosylated and expressed as a chimera with the Fc region of mouse immunoglobulin (heavy chain hinge, CH2 and CH3). Fc fusion proteins are typically more stable and resistant to degradation and clearance than native cytokines. Fc fusion proteins appear as a dimer in SDS-PAGE under non-reducing conditions.
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