丁基胆碱酯酶荧光活性试剂盒
The DetectX® Butyrylcholinesterase (BChE) Fluorescent Activity Kit measures BChE activity in a wide variety of samples, utilizing a proprietary non-fluorescent molecule, ThioStar®, which fluoresces when bound to the thiol reaction product of BChE and its substrate.

检测类型: Activity Assay
样本类型: Serum, Plasma (EDTA and Heparin)
灵敏度: 0.018 mU/mL
适用物种: 人, Chicken, Mouse, Rat, Dog, Monkey, Pig
检测时间: 20分钟
样品数/板: 40 in Duplicate
读数: Fluorescent, 510 nm Emission / 390 nm Excitation

背景:
Butyrylcholinesterase (BChE), found in the same structural class of proteins as acetylcholinesterase (AChE), is predominantly found in blood, kidneys, intestine, liver, lung, heart and the central nervous system. Species, such as human, horse and mice, exhibit high BChE plasma activity, whereas rats have higher acetylcholinesterase activity in plasma. In Alzheimer’s disease therapeutics, the use of potent cholinesterase inhibitors, acting on both AChE and BChE, protects limited endogenous acetylcholine levels found. As dementia advances, BChE activity has been shown to increase, while AChE activity decreases, leaving the potential for BChE activity to be used as a biomarker. BChE may also have roles in attention, executive function, emotional memory and behavior.