MPO被认为在低密度脂蛋白 (LDL) 的氧化和心血管疾病的进展中发挥作用。 该试剂盒已针对测量人血浆和组织样本中的 MPO“表达”进行了优化。 啮齿动物模型系统中的交叉反应性尚未经过测试。

Myeloperoxidase (MPO) is an iron containing protein tetramer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegener's disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention. Today it is regarded as one of the leading candidates for prognosis of cardiac disease. The classical MPO assay is an enzymatic assay for activity which can be hampered by the presence of inhibitory compounds in many tissue homogenates. The NWLSS™ MPO assay utilizes a unique buffer system to reduce the possible effects of loss of enzyme activity on enzyme detection.

格式:酶免疫分析法

用途:测量血浆、细胞培养液和其他可能存在MPO的生物液体中的人MPO

样品要求:血浆，组织和匀浆，以及其他可能存在MPO的生物液体

特异性:人髓过氧物酶

灵敏度:0.4 ng / mL

储存温度：2-8℃

Kit Contents:

Precoted Microwell strips and strip frames

Wash Buffer

Dilution Buffers A & B

Myeloperoxidase Standard

Biotinylated anti myeloperoxidase tracer

Streptavidin Peroxidase

TMB Substrate

Stop Solution