Protein C抗体

产品名称:

Murine Anti-Protein C抗体

Clone GMA-054

描述:
Thrombin, in the presence of thrombomodulin, cleaves protein C giving the active protease activated protein C (APC). APC plays a regulatory role in coagulation by functioning as an anticoagulant by proteolytic inactivation of Factors V (Va) and VIII (VIIIa). Protein C (Mr 62,000) consists of a heavy chain (Mr 41,000) disulfide bonded to a Gla-containing light chain (Mr 21,000) which contains two EGF domains. GMA-054 is calcium dependent, and recognizes the activation region of Protein C. It can be used in western blot and ELISA applications. GMA-054 does not recognize activated Protein C and inhibits activation of Protein C by thrombin-thrombomodulin.


物种反应性: Baboon, Canine, Human, Pig

来源: Murine

特异性: activation region of Protein C

免疫原: Human Protein C

同型: IgG1

应用
ELISA: Binds immobilized human protein C only in the presence of calcium.

Immunoblotting: Binds protein C under reduced and non-reduced conditions.

Inhibition: Inhibits activation of Protein C by thrombin-thrombomodulin.