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Murine Anti-Factor VIII抗体(GMA-8014)
货号:GMA-8014 | 规格:0.1 mg | 价格:¥0.00 | 品牌:Greenmoab
Factor VIII抗体,Murine Anti-Factor VIII抗体(GMA-8014)推荐用于ELISA和Inhibition应用。
Factor VIII抗体

产品名称:
Murine Anti-Factor VIII抗体
Clone GMA-8014

描述:
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor (vWF). Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8014 (also known as 3G6 or 3G6.1B)1 recognizes the C2 domain of FVIII. The antibody strongly inhibits FVIII activation and is unaffected by the presence of vWF or phospholipid membranes.1 GMA-8014 detects FVIII C2 domain by surface plasmon resonance,2,3 and is suitable for ELISA and bio-layer interferometry pairing experiments.


物种反应性: Human

来源: Murine

特异性: C2 Domain

免疫原: B-domain deleted recombinant Human Factor VIII

同型: IgG2b

应用
ELISA: Binds the C2 domain of recombinant human factor VIII in solid-phase ELISA..

Immunoblotting: Does not blot.

Inhibition: Strongly inhibitory in aPTT clotting assay.
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