Murine Anti-Factor VIII抗体(GMA-8018)
货号：GMA-8018
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规格：0.1 mg
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价格：￥0.00
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品牌：Greenmoab
Factor VIII抗体,Murine Anti-Factor VIII抗体(GMA-8018)推荐用于ELISA和Inhibition应用。
Factor VIII抗体
产品名称:
Murine Anti-Factor VIII抗体
Clone GMA-8018
描述:
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8018 (also known as 5G12 or 5G12.1B) recognizes the light chain of FVIII. It inhibits FVIII activation, and is suitable for ELISA applications.
物种反应性:
Human, Mouse, Pig
来源:
Murine
特异性:
Light Chain
免疫原:
B-domain deleted recombinant Human Factor VIII
同型:
IgG2a
应用
ELISA:
Binds immobilized human, porcine, and murine FVIII.
Immunoblotting:
Not recommended.
Inhibition:
Inhibitory in aPTT clotting assay.
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