Murine Anti-GPIba抗体(GMA-340)
货号：GMA-340
|
规格：0.5 mg
|
价格：￥0.00
|
品牌：Greenmoab
GPIba抗体,Murine Anti-GPIba抗体(GMA-340)推荐用于ELISA和Immunoblotting应用。
GPIba抗体
产品名称:
Murine Anti-GPIba抗体
Clone GMA-340
描述:
Platelet membrane glycoprotein Ib (GPIba) is comprised of an alpha and beta subunit linked by disulfide bonds. GPIba (also known as CD42b) is a 135 kDa membrane protein subunit that binds a variety of adhesive and procoagulant ligands, including von Willebrand factor. Cleavage of GPIba by the “sheddase” ADAM17 releases the ectodomain glycocalicin into plasma. ADAM17 cleaves GPIba at Gly464-Val465. Liang et al. have shown that the murine monoclonal antibody designated 5G6 (GMA-340) binds the ADAM17 cleavage site and blocks glycocalicin release.
物种反应性:
Human
来源:
Murine
特异性:
Shedding cleavage site of GPIba
免疫原:
Human GPIba peptide (Ac-ELDQPPKLRG VLQGHLESSRNDPFC- amide) conjugated to ovalbumin.
同型:
IgG1
应用
ELISA:
Binds immobilized human platelet GPIba and synthetic peptide
Immunoblotting:
Binds under reduced and non-reduced conditions
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