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Murine Anti-GPIba抗体(GMA-340)
货号:GMA-340 | 规格:0.5 mg | 价格:¥0.00 | 品牌:Greenmoab
GPIba抗体,Murine Anti-GPIba抗体(GMA-340)推荐用于ELISA和Immunoblotting应用。
GPIba抗体

产品名称:

Murine Anti-GPIba抗体


Clone GMA-340

描述:
Platelet membrane glycoprotein Ib (GPIba) is comprised of an alpha and beta subunit linked by disulfide bonds. GPIba (also known as CD42b) is a 135 kDa membrane protein subunit that binds a variety of adhesive and procoagulant ligands, including von Willebrand factor. Cleavage of GPIba by the “sheddase” ADAM17 releases the ectodomain glycocalicin into plasma. ADAM17 cleaves GPIba at Gly464-Val465. Liang et al. have shown that the murine monoclonal antibody designated 5G6 (GMA-340) binds the ADAM17 cleavage site and blocks glycocalicin release.


物种反应性: Human

来源: Murine

特异性: Shedding cleavage site of GPIba

免疫原: Human GPIba peptide (Ac-ELDQPPKLRG VLQGHLESSRNDPFC- amide) conjugated to ovalbumin.

同型: IgG1

应用
ELISA: Binds immobilized human platelet GPIba and synthetic peptide

Immunoblotting: Binds under reduced and non-reduced conditions
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