Human PAI-1 substrate form P12 glutamate mutant
货号：HPAI-A335E
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规格：1.0 mg
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价格：￥0.00
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品牌：Molecular Innovations
Human PAI-1 substrate form P12 glutamate mutant是由北京中昊新生科技有限公司提供，Molecular Innovations专注于凝血和溶栓试剂，包括PAI-876、tPA、尿激酶、凝血因子、玻连蛋白、纤维蛋白原、纤连蛋白、肾素原/肾素、前激肽释放酶、激肽释放酶、白蛋白、纤溶酶原、纤溶酶、抗纤溶酶、凝血酶、抗凝血酶、补体成分和免疫球蛋白。
From the laboratory of Professor Paul Declerck - Leuven BELGIUM. A single substitution at position P12 in the reactive center loop produces a PAI-1 that becomes a substrate for proteinases rather than an inhibitor. Reactive center loop insertion follows protease cleavage and the PAI-1 loses vitronectin binding properties. This molecule is useful for mechanistic studies.
References
1. Aertgeerts, K. et al. (1995) Proteins 23:118-121.
2. Aertgeerts, K. et al. (1995) Nat. Struct. Biol. 2:891-897.
3. Xue, Y. et al. (1998) Structure 6:627-636.
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