Human PAI-1 substrate form P14 arginine mutant
货号：HPAI-T333R
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规格：0.5 mg
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价格：￥0.00
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品牌：Molecular Innovations
Human PAI-1 substrate form P14 arginine mutant是由北京中昊新生科技有限公司提供，Molecular Innovations专注于凝血和溶栓试剂，包括PAI-899、tPA、尿激酶、凝血因子、玻连蛋白、纤维蛋白原、纤连蛋白、肾素原/肾素、前激肽释放酶、激肽释放酶、白蛋白、纤溶酶原、纤溶酶、抗纤溶酶、凝血酶、抗凝血酶、补体成分和免疫球蛋白。
A single substitution at position P14 in the reactive center loop produces a PAI-1 that becomes a substrate for proteinases rather than an inhibitor. Reactive center loop insertion follows protease cleavage and the PAI-1 loses vitronectin binding properties. This molecule is useful for mechanistic studies.
References
1. Lawrence, D.A. et al. (2000) J. Biol. Chem. 275:5839-5844.
2. Palmieri, D. et al. (2002) J. Biol. Chem. 277:40950-40957.
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