Non-enzymatic Human tPA
货号：HTPA-ALA
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规格：0.1 mg
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价格：￥0.00
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品牌：Molecular Innovations
Non-enzymatic Human tPA是由北京中昊新生科技有限公司提供，Molecular Innovations专注于凝血和溶栓试剂，包括PAI-991、tPA、尿激酶、凝血因子、玻连蛋白、纤维蛋白原、纤连蛋白、肾素原/肾素、前激肽释放酶、激肽释放酶、白蛋白、纤溶酶原、纤溶酶、抗纤溶酶、凝血酶、抗凝血酶、补体成分和免疫球蛋白。
This human tPA has an active site serine to alanine mutation which renders it catalytically inactive. The mutation site is S478A on the mature protein and S513A on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). It is >90percent single chain and retains exosite binding as well as other properties of wild type tPA. Recombinantly produced in insect cells.
Reference:
Identification of a conformationally distinct form of plasminogen
activator inhibitor-1, acting as a noninhibitory substrate for tissue-
type plasminogen activator
PJ Declerck, M De Mol, DE Vaughan, and D Collen
J. Biol. Chem., Jun 1992; 267: 11693 - 11696.
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