Non-cleavable Human tPA
货号:HTPA-NC
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规格:0.1 mg
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价格:¥0.00
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品牌:Molecular Innovations
Non-cleavable Human tPA是由北京中昊新生科技有限公司提供,Molecular Innovations专注于凝血和溶栓试剂,包括PAI-1003、tPA、尿激酶、凝血因子、玻连蛋白、纤维蛋白原、纤连蛋白、肾素原/肾素、前激肽释放酶、激肽释放酶、白蛋白、纤溶酶原、纤溶酶、抗纤溶酶、凝血酶、抗凝血酶、补体成分和免疫球蛋白。
The addition of an arginine to glutamic acid mutation generates human tPA that is 100percent single chain and resistant to cleavage by plasmin. The mutation site is R275E on the mature protein and R310E on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). Recombinantly produced in insect cells.
References:
1. Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis.
KM Tate, DL Higgins, WE Holmes, ME Winkler, HL Heyneker, and GA Vehar
Biochemistry, January 27, 1987; 26(2): 338-43.
2. Plasmin-Mediated Fibrinolysis by Variant Recombinant Tissue Plasminogen Activators
Shoko Urano, Alan R. Metzger, and Francis J. Castellino
PNAS, Apr 1989; 86: 2568 - 2571.
3. Plasminogen activation with single-chain urokinase-type plasminogen
activator (scu-PA). Studies with active site mutagenized plasminogen
(Ser740Ala) and plasmin-resistant scu-PA (Lys158Glu)
HR Lijnen, B Van Hoef, L Nelles, and D Collen
J. Biol. Chem., Mar 1990; 265: 5232 - 5236.
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