Factor VIII抗体

产品名称:
Murine Anti-Factor VIII抗体
Clone GMA-8009

描述:
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8009 (also known as 1D4 or 1D4.1B)1 recognizes the A2 domain of FVIII and inhibits FVIII activation by thrombin or factor Xa. It is suitable for immunohistochemistry and FACS2, ELISA and bio-layer interferometry pairing experiments.


物种反应性: Human

来源: Murine

特异性: FVIII A2 domain (residues Glu604-Arg740)1

免疫原: B-domain deleted recombinant Human Factor VIII

同型: IgG2a

应用
ELISA: Binds the A2 domain of recombinant human factor VIII in solid-phase ELISA.

Immunoblotting: Not recommended.

Inhibition: Strongly inhibitory in aPTT clotting assay.