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Murine Anti-Factor VIII抗体(GMA-8026)
货号：GMA-8026 | 规格：0.5 mg | 价格：￥0.00 | 品牌：Greenmoab
Factor VIII抗体,Murine Anti-Factor VIII抗体(GMA-8026)推荐用于ELISA和Inhibition应用。
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Factor VIII抗体

产品名称:

Murine Anti-Factor VIII抗体


Clone GMA-8026

描述:
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor. Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8026 (also known as G99)1 recognizes the C2 domain of FVIII through the Pro2221-Trp2229 loop2, inhibits FVIII activation by thrombin or factor Xa, and is unaffected by FVIII binding to vWF.3


物种反应性: Human

来源: Murine

特异性: C2 Domain

免疫原: B-domain deleted recombinant Human Factor VIII

同型: IgG2a

应用
ELISA: Binds immobilized human FVIII.

Immunoblotting: Not recommended.

Inhibition: Strongly inhibitory in aPTT clotting assay.
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