HPV11 E6抗体

描述:Goat polyclonal antibody to HPV11 E6. E6 is one primary oncoprotein of high risk HPV types expressed early in the HPV life cycle. After the host cell is infected viral early promoter is activated and a polycistronic primary RNA containing all six early ORFs is transcribed. This polycistronic RNA then undergoes active RNA splicing to generate multiple isoforms of mRNAs. One of the spliced isoform RNAs, E6, serves as an E7 mRNA to translate E7 protein. HPV genome integrate into host genome by disruption of E2 ORF, preventing E2 repression on E6 and E7. Thus, viral genome integration into host DNA genome increases E6 expression. The E6 protein inactivates the tumour suppressor protein, p53 and promote cellular proliferation and the chance of malignancy.

浓度: 3 mg/ml

抗体类型: 一抗.

Target Name: Anti-HPV11 E6

宿主: Goat

免疫原物种: HPV11

免疫原类型: Recombinant protein

免疫原: Purified recombinant peptide derived from within residues 65 aa to N-terminal of HPV11 E6 produced in E. coli.

亚型: IgG

克隆: Polyclonal

已确认的反应种属: Human papilloma viruses type 11

特异性: Detects HPV11 E6 recombinant fusion proteins MBP-E6 and GFP-E6 expressed in transfected mammalian cells.

储存缓冲液: PBS, 20% glycerol and 0.05% sodium azide

纯化: Epitope affinity purified

偶联物: Unconjugated

RRID: AB_2333146

经验证的应用: WB

推荐稀释: WB:1:500-1:2,000

储存条件: Store at -20 C for long-term storage. Store at 2-8 C for up to one month.



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