BML-210
货号：P013-5MG
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规格：5MG
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价格：￥0.00
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品牌：Arbor Assays
Arbor Assays BML-210,CAS号537034-17-6,强效HDAC小分子抑制剂,增加A549乙酰化组蛋白水平,通过SIRT抑制转录因子FOXO3。
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Use:
Potent HDAC Inhibitor
Increases A549 acetylated histone levels
Inhibits transcription factor FOXO3 by SIRT
描述:
Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation. BML-210 is a small molecule inhibitor of HDAC with an IC50 value of 5-10 uM when tested in HeLa cell nuclear extracts. BML-210 also inhibits the deacetylation of the transcription factor FOXO3 by mammalian SIRT1 in cells oxidatively stressed by hydrogen peroxide.
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