EX-527
货号：P005-5MG
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规格：5MG
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价格：￥0.00
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品牌：Arbor Assays
Arbor Assays EX-527,CAS:49843-98-3,一种细胞渗透选择性SIRT1抑制剂,不抑制HDAC,p53的SIRT1去乙酰化抑制剂。
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特性:
Selective SIRT1 inhibitor
Does not inhibit HDACs
Inhibitor of SIRT1 deacetylation of p53
描述:
EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM in vivo, 38nM in vitro) that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 20 uM, 49 uM, > 100 uM and > 100 uM for SIRT2, SIRT3, HDAC and NADase respectively). EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.
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