FK-866,NAMPT抑制剂|中昊生物

FK-866 HCl

货号：P006-25MG | 规格：25MG | 价格：￥0.00 | 品牌：Arbor Assays

Arbor Assays FK-866 HCl是NAMPT抑制剂,CAS:658084-64-1,SIRT1间接抑制剂,可导致NAD+逐渐耗竭。
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特性:
Specific inhibitor of NAMPT
Indirect inhibitor of SIRT1
Causes gradual NAD+ depletion
描述:
FK-866 is a selective inhibitor of the nicotinamide pathway dependent NAD+ synthesis, causing NAD+ depletion. Highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT/NAPRT) for both the substrate complex and the free enzyme (Ki=0.4 nM and Ki´=0.3 nM, respectively). NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC50=~1 nM). Causes premature senescence in normal human smooth muscle cells, an effect that may be linked to decreased activity of the NAD+-dependent enzyme SIRT1.

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