BIX-01294,CAS:1392399-03-9|中昊生物

BIX-01294

货号：P018-25MG | 规格：25MG | 价格：￥0.00 | 品牌：Arbor Assays

Arbor Assays BIX-01294,CAS:1392399-03-9,选择性,细胞可渗透性G9a/GLP HMTase抑制剂,IC50值分别为0.7和1.7μM。
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特性:
Inhibitor of G9a and GLP HMTases
Cell permeable
Selectively impairs generation of Histone H3K9me2
描述:
BIX-01294, a diazepin-quinazolinamine derivative, is a selective,cell-permeable G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 0.7 and 1.7 uM respectively) that displays little or no activity at other HMTases. BIX-01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro. BIX-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.

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