IBMX,PDES抑制剂,CAS:28822-58-4|中昊生物

IBMX

货号：P019-100MG | 规格：100MG | 价格：￥0.00 | 品牌：Arbor Assays

Arbor Assays IBMX,CAS:28822-58-4,泛特异性PDEs抑制剂,能增强细胞内cAMP和cGMP水平,激活蛋白激酶。
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特性:
Pan-specific inhibitor of PDEs
Increases cellular cAMP and cGMP
Activates protein kinases
Storage at room temperature
描述:
IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50s from 7 to 50 µM for PDE1-5, PDE7, and PDE11. PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists. Suppresses alpha-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 µM).

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