5-Azacytidine
货号：P012-250MG
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规格：250MG
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价格：￥0.00
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品牌：Arbor Assays
Arbor Assays 5-Azacytidine/5-氮杂胞苷,CAS:320-67-2,是DNA甲基转移酶抑制剂,阻断G1细胞周期进程,诱导HIV-1启动子激活。
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特性:
DNA Methyltransferase inhibitor
Blocks cell cycle progression at G1
Induces activation of HIV-1 promoter
描述:
Incorporates into DNA, forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells. Methyltransferases in the presence of azacitidine incorporate it into DNA during replication and into RNA during transcription in the cell. Azacytidine acts as a false substrate and potent inhibitor of methyltransferases leading to reduction of DNA methylation.
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