Miropin (Tannerella forsythia serine protease inhibitor)
货号：MIRO-HIS
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规格：0.01 mg
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价格：￥0.00
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品牌：Molecular Innovations
Miropin (Tannerella forsythia serine protease inhibitor)是由北京中昊新生科技有限公司提供，Molecular Innovations专注于凝血和溶栓试剂，包括PAI-1289、tPA、尿激酶、凝血因子、玻连蛋白、纤维蛋白原、纤连蛋白、肾素原/肾素、前激肽释放酶、激肽释放酶、白蛋白、纤溶酶原、纤溶酶、抗纤溶酶、凝血酶、抗凝血酶、补体成分和免疫球蛋白。
Miropin is a prokaryotic serpin (SErine Protease INhibitor) protein from Tannerella forsythia, a human pathogen involved in the pathogenesis of periodontitis. Miropin can inhibit the activity of a broad range of proteases including trypsin, cathepsin G, neutrophil and pancreatic elastases. Therefore, miropin is a unique serpin in its wide range of inhibitory activity. Recombinantly produced in insect cell culture and purified by chelated metal affinity chromatography. Contains a 8X-Histidine tag at the N terminus for purification. This recombinant miropin inhibits the activity of human neutrophil elastase in vitro. At least 95percent pure as determined by SDS-PAGE.
References:
1. Ksiazek, M., Mizgalska, D., Enghild, J.J., Scavenius, C.,Thogersen, I.B., and Potempa, J. Miropin, a Novel Bacterial Serpin from the Periodontopathogen Tannerella forsythia, Inhibits a Broad Range of Proteases by Using Different Peptide Bonds within the Reactive Center Loop. (2015) J. Biol. Chem. 290: 658-670.
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