SAHA (Vorinostat )
货号：P004-50MG
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规格：50MG
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价格：￥0.00
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品牌：Arbor Assays
Arbor Assays SAHA(Vorinostat),HDAC抑制剂,CAS:149647-78-9,应用于皮肤T细胞淋巴瘤的治疗,体外和体内对潜伏性HIV感染T细胞影响的研究。
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特性:
HDAC inhibitor
Cutaneous T-cell lymphoma treatment
In vitro and in vivo effects on latent HIV infected T-Cells
Storage at room temperature
描述:
SAHA (suberoylanilide hydroxamic acid, Vorinostat, Zolinza™) is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. Sirt activator based on a dihydropyridine structural scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) is 1 uM for Sirt1, 25 uM for Sirt2, and 50 uM for Sirt3. The compound is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. SAHA inhibits class I and class II HDACs at around 50 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 uM.
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