FK-866 HCl,CAS:658084-64-1|中昊生物

FK-866 HCl

货号：P006-5MG | 规格：5MG | 价格：￥0.00 | 品牌：Arbor Assays

Arbor Assays FK-866 HCl,CAS:658084-64-1是NAMPT inhibitor(NAMPT抑制剂),SIRT1间接抑制剂,可导致NAD+逐渐耗竭。
北京中昊新生是Arbor Assays中国代理商,我们很荣幸为您的研究提供产品订购以及帮您解决产品所有的技术问题。

产品说明说明书相关产品相关资料

特性:
Specific inhibitor of NAMPT
Indirect inhibitor of SIRT1
Causes gradual NAD+ depletion
描述:
FK-866 is a selective inhibitor of the nicotinamide pathway dependent NAD+ synthesis, causing NAD+ depletion. Highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT/NAPRT) for both the substrate complex and the free enzyme (Ki=0.4 nM and Ki´=0.3 nM, respectively). NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC50=~1 nM). Causes premature senescence in normal human smooth muscle cells, an effect that may be linked to decreased activity of the NAD+-dependent enzyme SIRT1.

上一篇：Phenylbutyrate, Na Salt

下一篇：FK-866 HCl

返回列表