C-646,CAS:328968-36-1 |中昊生物

C-646

货号：P014-5MG | 规格：5MG | 价格：￥0.00 | 品牌：Arbor Assays

Arbor Assays C-646,CAS:328968-36-1,是p300/CBP HAT抑制剂,抑制黑色素瘤癌细胞生长,对其他HATs的抑制率低于10%,Ki=400 nM。
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特性:
p300/CBP HAT inhibitor
Inhibits melanoma cancer cell growth
Less than 10% inhibition of other HATs
Storage at 4°C
描述:
A reversible, cell-permeable pyrazolone p300/CBP HAT inhibitor (Ki = 400 nM), which competes with acetyl-CoA for the p300 Lys-CoA binding pocket. Demonstrates 86% inhibition against p300 at 10 nM. Less than 10% inhibition against serotonin N-acetyltransferase, PCAF, GCN5, Rtt109, Sas, and MOZ HATs in a chemical screening assay. Treatment of C3H 10T1/2 mouse fibroblasts at 25 uM results in an inhibitory effect against basal and TSA-inducible acetylation of histones H3 and H4. Shown to inhibit human cell growth in melanoma and non-small cell-lung cancer cell lines at 10 uM with similar or higher potency than peptide-based bisubstrate p300/CBP HAT inhibitor Lys-CoA-Tat at 25 uM.

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